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MAINTAINED. Please visit my page via the university portal.
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-What are the mechanisms in the brain that makes us learn and
remember?
-More specifically, what are the molecular
mechanisms in synapses that enables learning and memory?
-What
computational operations are performed by the molecules in the
postsynaptic density?
We study these questions by
computational modeling using data from experimental partners.
In our research, we study mechanisms of synaptic transmission and
mechanisms of how this transmission is altered as a result of
learning and for the purpose of memory encoding. In this work, we
use mathematical modeling and computer simulation. The synapse and
its ion channels and postsynaptic density proteins are described
by differential equations which are solved numerically in a
specialized computer program. Results of the simulations are
compared to experiments where the biochemical or electrical
activity was measured. We work together with biomedical
experimental labs, for this project dr
Seth Grant.
-What activity in a sensory nerve fiber make you experience
pain?
-What have changed in a nerve fiber when a patient
suffers from chronic pain?
-Further, how can we affect a
diseased nerve fiber to reduce pain?
We study these
questions by computational modeling using data from experimental
partners.
In our research, we study
mechanisms behind chronic pain. In particular we study the changes
after inflammation, injury or disease of nerves in legs and arms.
We also study how properties of malfunctioning neurons can be
changed towards more healthy function by mimicing effects by drugs
on ion channels. We apply these methods to pain and epilepsy. In
this work, we use mathematical modeling and computer simulation.
The neurons, ion channels and biochemical reactions are described
by differential equations which are solved numerically in a
specialized computer program. Results of the simulations are
compared to experiments where the electrical activity was
measured, either in a patient, healthy volunteer, an animal under
aenesthesia or in a piece of brain tisssure or a cultivated
neuron. We work together with biomedical experimental labs, for
example dr
Martin Schmelz.
Nobel
Prize in physiology or medicine 2014 to John O'Keefe,
May-Britt Moser and Edvard Moser for groundbreaking studies of how
hippocampus and entorhinal cortex provide our brain with the
capacity for mapping the space around us so that we can locate
ourselves and navigate in the world. In our laboratory, we
studied properties of entorhinal cortex neurons and hippocampal
neurons and how these properties relate to the grid fields that
Moser & Moser have found, and how the rhythmicity of this
brain region, fundamental to the studies pioneered by O'Keefe,
emerges from interactions between cellular and synaptic network
interactions. Read more about our work here.
Popular science article: Read more about our work in
computational pharmacology here...
Read more about highlights in our research here...
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