@Misc{patirniche16,
  author       = {D.~Patirniche and M.~Breit and T.~Weinkauf and E.~Bushong and S.~ Phan and G.~Queisser and M.~Ellisman and A.~Herz},
  title        = {Comparative Ultrastructural Anatomy Of Dendritic Spines},
  howpublished = {CRCNS Conference Poster, Paris, October 24--26, 2016},
  month        = {October},
  year         = {2016},
  abstract     = {The synaptic weight, a central concept in numerous neuroscience studies,
              is still lacking a proper biophysical foundation at the level of
              macromolecular assemblies. Given their intrinsic morphological plasticity,
              dendritic spines are prime candidates to modulate synaptic weights.
              Understanding the structural dynamics of spines is thus key to understanding
              synaptic transmission and plasticity. So far, electron microscopy
              tomography (EMT) is the only imaging method that provides an isotropic
              resolution that is sufficient to study the ultrastructural anatomy
              of these ubiquitous structures. Applying an advanced topological
              segmentation-algorithm (Günther et al., Computer Graphics Forum 31,
              2012) to analyze EMT image stacks, we were able to extract the entire
              actin cytoskeleton of individual spines from the mouse cerebellar
              and hippocampal formations. Here, we present results of this methodological
              pipeline, focusing on the cytoskeletal organization as morphological
              alterations of dendritic spines are always driven by changes of the
              underlying macromolecular structure that provides their mechanical
              stability.},
  url = {http://tinoweinkauf.net/publications/abspatirniche16.html},
}