(Giocomo et al, Science, 2007)
(Fransén et al, Neuron, 2006)
(Egorov et al, Nature, 2002)
(Fransén et al, J. Neurosci, 2002)
| Origin of entorhinal cortex grid field
spacing. In entorhinal cortex, stellate cell
oscillation frequency correlates with grid field size. Modeling shows
that variation in HCN-channel characteristics may underlie the
gradient in stellate cell oscillation frequency and that cells with
these properties may result in grid field-like firing patterns when
included in a virtual rat. (Giocomo et al, Science, 2007) | |
| Origin of intrinsic graded firing
levels. Modeling shows that graded levels in entorhinal cortex may
depend on two separate pathways whose activation is separated by a
neutral region. Further, graded levels do not depend on intracellular calcium
stores, and they do not appear to be discretely spaced. (Fransén et al, Neuron, 2006) | |
| Pyramidal cells in entorhinal cortex
show intrinsic graded levels of firing. These levels can also be upgraded
or downgraded by synaptic stimulation. Graded levels depend on
intracellular calcium and of a mixed cation channel (TRP-type)
activated by muscarinic receptors. (Egorov et al, Nature, 2002) | |
| Working memory function depending on
medial temporal lobe structures may depend on activation of a mixed
cationic ion channel in entorhinal cortex pyramidal neurons. A
simulated small network shows the functional cell classes found in
behavioural experiments, like delay cells or match enhancement cells. (Fransén et al, J. Neurosci, 2002) |
