PUBLICATIONS for Jeanette Hellgren Kotaleski (please send an email for questions)

Articles (contributions in refereed journals):

Klaus A, Planert H, Hjorth JJ, Berke JD, Silberberg G, Kotaleski JH (2011) Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact, Frontiers Syst Neurosci. 5:57 PubMed

Kamali Sarvestani I, Lindahl M, Hellgren-Kotaleski J, Ekeberg O (2011) The arbitration-extension hypothesis: a hierarchial interpretation of the functional organization of the Basal Ganglia, Front Sys Neurosci. 5:13 PubMed

Manninen T, Hituri K, Kotaleski JH, Blackwell KT, Linne ML (2010) Postsynaptic signal transduction models for long-term potentiation and depression, Frontiers Computational Neurosci. 4:152 PubMed

Kotaleski JH, Blackwell KT (2010) Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches, Nature Reviews Neurosci. 11:239-251 PubMed

Djurfeldt M, Hjorth J, Eppler JM, Dudani N, Heliaz M, Potjans TC, Bhalla US, Diesmann M, Kotaleski JH, Orjan Ekeberg (2010) Run-Time Interoperability Between Neuronal Network simulators Based on the MUSIC Framework, Neuroinformatics, 8:43-60 PubMed

Kozlov A, Huss M, Lansner A, Kotaleski JH, Grillner S (2009) Simple cellular and network control principles govern complex patterns of motor behavior, PNAS, 106(47):20027-32 PubMed

Halnes G, Ulfhielm E, Eklof Ljunggren E, Kotaleski JH, Rospars JP (2009) Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertrebrate olfactory receptor neurons , J Comput Neurosci 27:471-491 PubMed

Sandstrom M, Lansner A, Hellgren-Kotaleski J, Rospars JP (2009) Modeling the response of a population of olfactory receptor neurons to an odorant , J Comput Neurosci, 27:337-355 PubMed

Hjorth J, Blackwell KT, Kotaleski JH (2009) Gap junctions between striatal fast-spiking interneurons regulate spiking activity and synchronization as a function of cortical activity , J Neurosci, 29:5276-86 PubMed

Huss M, Wang D, Trane C, Wikstrom M, Hellgren Kotaleski J (2008) An experimentally constrained computational model of NMDA oscillations in lamprey CPG neurons , J Comput Neurosci, 25:108-21 PubMed

Grillner S, Kozlov A, Dario P, Stefanini C, Menciassi A, Lansner A, Hellgren Kotaleski J (2007) Modeling a vertebrate motor system: pattern generation, steering and control of body orientation , Prog Brain Res, 165:221-34 PubMed

Huss M, Lansner A, Wallen P, El Manira A, Grillner S, Kotaleski JH (2007) Roles of ionic currents in lamprey CPG neurons: a modeling study , J Neurophysiol, 97:2696-711 PubMed

Kozlov AK, Lansner A, Grillner S, Hellgren Kotaleski J (2007) A hemicord locomotor network of excitatory interneurons: a simulation study , Biol Cybern, 96:229-43 PubMed

Hjorth J, Hanna Elias A, Hellgren Kotaleski J (2007) The significance of gap junction location in striatal fast spiking interneurons , Neurocomputing 70:1887-1891 Link

Sandström M, Hellgren Kotaleski J, Lansner A (2007) Scaling effects in a model of the olfactory bulb Neurocomputing 70:1802-1807 Link

Samuelsson E, Hellgren Kotaleski J (2007) Exploring GABAergic and dopaminergic effects in a minimal model of a medium spiny projection neuron Neurocomputing 70:1615-1618 Link

Westermark PO, Hellgren Kotaleski J, Grill V, Björklund A, Lansner A (2007) A mathematical model of the mitochondrial NADH shuttles and anaplerosis in the pancreatic beta-cell Am J PhysiolEndocrinol Metab, 292:E373-93 PubMed

Lindskog M, Kim MS, Wikström MA, Blackwell KT, Hellgren Kotaleski J (2006) Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation PLoS Computational Biology, 2(9):e119 PubMed

Sandström M, Hjorth J, Lansner A, Hellgren Kotaleski J (2006) The impact of the distribution of isoforms on CaMKII activation Neurocomputing 69:1010-1013 Link

Huss M, Cangiano L, Hellgren Kotaleski J (2006) Modelling self-sustained rhythmic activity in lamprey hemisegmental networks Neurocomputing 69:1097-1102 Link

Kotaleski JH, Plenz D, Blackwell KT (2006) Using potassium currents to solve signal noise problems in inhibitory feedforward networks of the striatum. Journal of Neurophysiology 95:331-41 PubMed

Grillner S, Kozlov A, Kotaleski JH (2005) Integrative neuroscience: linking levels of analyses. Current Opinion in Neurobiology, 15:614-21 PubMed

Grillner S, Kotaleski JH, Menard A, Saitoh K, Wikström M (2005) Mechanisms for selection of basic motor programs--roles for the striatum and pallidum. Trends in Neuroscience 28:364-70 PubMed

De Schutter E, Ekeberg Ö, Hellgren Kotaleski J, Archard P, Lansner A (2005) Biophysically detailed modelling of microcircuits and beyond. Trends in Neuroscience 28:562-9 PubMed

Hellgren Kotaleski J, Plenz D, Blackwell KT (2005) The role of background synaptic noise in striatal fast spiking interneurons. Neurocomputing, 65-66:727-732 Link

Svantesson A, Westermark PO, Kotaleski JH, Gharizadeh B, Lansner A, Nyren P (2004) A mathematical model of the Pyrosequencing reaction system. Biophysical Journal 110:129-45 PubMed

Westermark PO, Hellgren Kotaleski J, Lansner A (2004) Derivation of a reversible Hill equation with modifiers affecting catalytic properties, WSEAS Transactions on Biology and Biomedicine 1:91-98 pdf

Westermark PO, Hellgren Kotaleski J, Lansner A (2004) Glucose-stimulated insulin secetion - Insights from modelling Recent Res. Devel. Biophys. 3:325-350 or pdf

Hallen K, Huss M, El Manira A, Kettunen P, Hellgren Kotaleski J (2004) mGluR-mediated calcium oscillations in the lamprey - a computational model. Neurocomputing 58-60:431-35 Link

Huss M, Lamotte d'Incamps B, El Manira A, Lansner A, Hellgren Kotaleski J (2003) Role of A-current in lamprey locomotor network neurons. Neurocomputing, 52-54: 295-300 Link

Kotaleski JH, D Lester, KT Blackwell (2002) Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval. Integr Physiol Behav Sci, 37:265-292 PubMed or pdf

Hellgren Kotaleski J, KT Blackwell (2002) Sensitivity to interstimulus interval due to calcium interactions in the Purkinje cell spines. Neurocomputing, 44-46:13-18 Link

Kozlov AK, Aurell E, Orlovsky GN, Deliagina TG, Zelenin PV, Hellgren-Kotaleski J, Grillner S (2001) Modeling postural control in the lamprey. Biological Cybernetics, 84: 323-330 PubMed

Kozlov AK, Kotaleski JH, Aurell E, Grillner S, Lansner A (2001) Modeling of substance P and 5-HT induced synaptic plasticity in the lamprey spinal CPG - consequences for network pattern generation. Journal of Computational Neuroscience 11:183-200 PubMed

Yang K-H, Hellgren Kotaleski J, Blackwell KT (2001) The role of protein kinase C in the biochemical pathways of classical conditioning. Neurocomputing, 38-40:79-85 Link

Hellgren Kotaleski J, Krieger, P (2000) Simulation of metabotropic glutamate receptor induced effects in the lamprey CPG. Neurocomputing 32-33:433-439 Link

Kozlov A, Hellgren Kotaleski J, Aurell E, Grillner S, Lansner A (2000) Modeling of plasticity of the synaptic connections in the lamprey spinal CPG - consequences for network behavior. Neurocomputing 32-33:441-446 Link

Kozlov A, Aurell E, Deliagina T, Grillner S, Hellgren-Kotaleski J, Orlovsky G, Zelenin P. (2000). Modeling control of roll-plane body orientation in lamprey. Neurocomputing 32-33:871-877 Link

Krieger P, Hellgren-Kotaleski J, P Kettunen, El Manira AJ (2000) Interaction between metabotropic and ionotropic glutamate receptors regulates neuronal network activity. Journal of Neuroscience 20:5382-5391 PubMed

Kotaleski JH, Grillner S, Lansner A (1999) Neural mechanisms potentially contributing to the intersegmental phase lag in lamprey. I: Segmental oscillations dependent on reciprocal inhibition. Biological Cybernetics 81: 317-330 PubMed

Kotaleski JH, Lansner A, Grillner S (1999) Neural mechanisms potentially contributing to the intersegmental phase lag in lamprey. II: Hemisegmental oscillations produced by mutually coupled excitatory neurons. Biological Cybernetics 81: 299-315 PubMed

Hellgren Kotaleski J, Tegner J, Lansner A, Grillner S (1999) Control of burst proportion and frequency range by drive-dependent modulation of adaptation. Neurocomputing, 26-27: 185-191 Link

Tegnér J, Hellgren Kotaleski J (1999) The synaptic NMDA component desynchronizes neural bursters. Neurocomputing, 26-27: 557-563 Link

Ullström M, Kotaleski JH, Tegnér J, Aurell E, Grillner S, Lansner A (1998) Activity dependent modulation of adaptation produces a constant burst proportion in a lamprey neural network model. Biological Cybernetics 79:1-14 PubMed

Tegnér J, Hellgren-Kotaleski J, Lansner A, Grillner S (1997) Low voltage activated calcium channels in the lamprey locomotor network - simulation and experiment. Journal of Neurophysiology 77:1795-1812 PubMed

Wadden T, Hellgren J, Lansner, Grillner S (1997) Intersegmental coordination in the lamprey: Simulations using a network model without segmental boundaries. Biological Cybernetics 76:1-9 Link

Wikström M, Hill RH, Hellgren J, Grillner S (1995) The action of 5-HT on calcium-dependent potassium channels and on the spinal locomotor network in lamprey is mediated by 5-HT1A-like receptors. Brain Res 678:191-199 PubMed

Brodin L, Shupliakov O, Pieribone V, Hellgren J, Hill RH (1994) The reticulospinal glutamate synapse in lamprey: plasticity and presynaptic variability. Journal of Neurophysiology 72: 592-604 PubMed

Hellgren J, Grillner S, Lansner A (1992) Computer simulation of the segmental neural network generating locomotion in lamprey by using populations of network interneurons. Biological Cybernetics 68:1-13 PubMed

Hellgren J, Kellerth J-O (1989) A physiological study of the monosynaptic reflex responses of cat spinal alpha-motoneurons after lumbusacral deafferentation. Brain Res 488:149-162 PubMed

Books, review articles, book chapters, technical reports:

Lindskog M, Halnes G, Olieveira RF, Hellgren Kotaleski J, Blackwell KT (2010) Biochemical networks in psychiatric disease, In: Systems biology in Psychiatric Research: From High-Throughput data to mathematical modeling, Eds: Tretter F, Gebicke-Haerter PJ, Mendoza E, Winterer G; ISBN-10:3-527-32503-4 - Wiley-VCH.

Svantesson A, Nordstrom T, Hellgren Kotaleski J, Nyren P (2005) An investigation of the Apyrase Step in the Pyrosequencing Model: Combining Experiments and Simulations, Dept. of Numerical Analysis and Computing Science, KTH, TRITA-NA-P0509

Svantesson A, Westermark PO, Nyren P, Hellgren Kotaleski J (2005) Towards an Improved Polymerase Description in the Pyrosequencing Model, Dept. of Numerical Analysis and Computing Science, KTH, TRITA-NA-P0510

Blackwell KT, Hellgren Kotaleski J (2002) Modeling the dynamics of second messenger pathways, In: Neuroscience Databases: a Practical Guide, Ed R Kötter, Kluwer Academic Publishers, Norwell, MA. pdf

Hellgren Kotaleski J, Lansner A (1999) Modeling Cellular Processes - Bioinformatics beyond Sequences. Dept. of Numerical Analysis and Computing Science, Kungliga Tekniska Högskolan, TRITA-NA-P9906.

Lansner A, Kotaleski JH, Grillner S (1998) Modeling the spinal circuitry underlying locomotion in a lower vertebrate. In: Neuronal Mechanisms for Generating Locomotor Activity (eds: Kiehn O, Harris-Warrick R M, Jordan L M, Hultborn H, Kodo N), Ann. N. Y. Acad. Sci. 860:239-249 (invited paper) PubMed

Hellgren Kotaleski J (1998) Modeling of Bursting Mechanisms and Coordination in a spinal Pattern Generator. PhD thesis, Department of Numerical Analysis and Computing Science, Kungliga Tekniska Högskolan, Stockholm, TRITA-NA-9810.

Hellgren J. (1989) A Physiological and Morphological Study of the Plasticity of Primary Afferent Projections to the Cat Spinal Motor Nuclei Following Partial Lumbosacral Deafferentation. Licentiate thesis, Department of anatomy, University of Umeå.

Conferences, abstracts, etc:

Fino E, Paille V, Du K, Morera Herreras T, Hellgren Kotaleski J, Venance L (2011) GABA operates as a Hebbian/anti-Hebbian switch for spike-timing-dependent plasticity , SFN poster 348.03/N5

Brandi M, Brocke E, Talukdar HA, Hanke M, Bhalla US, Djurfeldt M, Kotaleski J (2011) Multiscale modeling through MUSIC multi-simulation: Modeling a dendritic spine using MOOSE and NeuroRD, 4th INCF Congress, Boston Link

Lindahl M, Kotaleski J (2011) Short term plasticity within the basal ganglia - a systems level computational investigation , BMC Neuroscience 2011, 12(Suppl 1):P145 (CNS 2011) Link

Brandi M, Brocke E, Talukdar HA, Hanke M, Bhalla US, Kotaleski J, Djurfeldt M (2011) Connecting MOOSE and NeuroRD through MUSIC: towards a communication framework for multi-scale modeling , BMC Neuroscience 2011, 12(Suppl 1):P77 (CNS 2011) Link

Paille V, Du K, Deniau J-M, Hellgren Kotaleski J, Fino E, Venance L (2010) GABAergic microcircuits govern the corticostriatal spike-timing dependent plasticity, IBAGS X Abstract

Lindahl M, Hellgren Kotaleski J (2010) Action selection in the basal ganglia - a computational investigation, FENS Abstract

Hjorth J, Blackwell KT, Hellgren Kotaleski J (2010) FS networks as population detectors of correlated input activity, IBAGS X (abstract, invited talk)

Hellgren Kotaleski J, Grillner S (2010) Networks in motion - bridging between intrinsic mechanisms and systems level function (invited talk, symposium at Colegio Nacional in Mexico City, March 2010)

Hellgren Kotaleski J (2010) The functions of the striatal microcircuitry - a modeling approach (invited talk, FENS)

Ericsson J, Stephenson-Jones MR, Samuelsson E, Robertson B, Hill RH, Hellgren-Kotaleski J, Grillner S (2010) The lamprey provides a vertebrate blueprint of the mammalian basal ganglia FENS Abstract

Robertson B, Jones M, Samuelsson E, Hill R, Hellgren J, Grillner S (2009) The lamprey basal ganglia - A vertebrate blue-print Society for Neuroscience Abstract, 17-21 Oct, Chicago (poster, abstract)

Evans RC, Du K, Sheehan T, Hellgren Kotaleski J, Blackwell KT (2009) Effects of NMDA receptor NR2 subunit on calcium concentration Society for Neuroscience Abstract, 17-21 Oct, Chicago (poster, abstract)

Klaus A, Hjorth J, Hellgren Kotaleski J (2009) The influence of stuttering properties for firing activity in pairs of electrically coupled striatal fast-spiking interneurons 2nd INCF Congress of Neuroinformatics, 6-8 Sept, Pilsen (poster, abstract) Link

Samuelsson E, Hill R, Hellgren-Kotaleski J (2009) The basal ganglia output stage in the lamprey - a combined experimental and modeling study 2nd INCF Congress of Neuroinformatics, 6-8 Sept, Pilsen (poster, abstract) Link

Hellgren Kotaleski J (2009) Modelling of motor systems including the dynamics in intracellular signaling networks involved in learning and synaptic plasticity British Neuroscience Association Meeting 2009, Liverpool (invited talk, abstract)

Samuelsson E, Hill R, Hellgren Kotaleski J (2009) Exploration of the lamprey pallidal neurons - a combined computational and experimental study CNS 2009, 18-23 July, Berlin, Germany (poster) Link

Klaus A, Hjorth J, Hellgren-Kotaleski J (2009) The influence of subthreshold membrane potential oscillations and GABAergic input on firing activity in striatal fast-spiking neurons CNS 2009, 18-23 July, Berlin, Germany (poster) Link

Klaus A, Kotaleski JH (2008) Synchronization effects between striatal fast-spiking interneurons forming networks with different topologies 1st INCF Congress of Neuroinformatics, Sept, Stockholm (poster, abstract) Link

Hjorth J, Krieger P, Oliveira RF, Blackwell KT, Kotaleski JH (2008) GABAergic control of dendritic calcium dynamics in striatal medium spiny neurons 1st INCF Congress of Neuroinformatics, Sept, Stockholm (poster, abstract) Link

Hjorth J, Blackwell KT, Hellgren Kotaleski J (2008) Gap junctions on striatal fast spiking interneurons reduce firing for non-correlated inputs Society for Neuroscience Abstract, 15-19 Nov, Washington DC, (poster, abstract)

Halnes G, Ulfhielm E, Kotaleski JH, Rospars JP (2008) Modeling of the receptor, G-protein and effector reactions in vertebrate olfactory receptor neurons CNS 2008, 19-24 July, Portland, Oregon, US (selected for oral presentation) Link

Hjorth J, Zilberter M, Oliveira RF, Blackwell KT, Hellgren Kotaleski J (2008) GABAergic control of backpropagating action potentials in striatal medium spiny neurons CNS 2008, 19-24 July, Portland, Oregon, US (poster) Link

Ritz R, Hellgren Kotaleski J, Strandberg P, Larsson A, Lillberg Y, Chatzopoulou E, Holm P, Naeslund M, Wang H, Bjaalie JG (2008) A new software center for the neuroinformatics community CNS 2008, 19-24 July, Portland, Oregon, US (poster) Link

Hjorth J, Hedlund L, Blackwell KT, Hellgren Kotaleski J (2008) Synchronization effects in networks of striatal fast spiking interneurons - role of gap junctions (invited for oral presentation) In: Proceedings of the International Conference on Cognitive Neurodynamics, ICCN 2007, Link

Hellgren Kotaleski J (2007) Subcellular temporal computation and its role for synaptic plasticity IBAGS IX, The Netherlands (invited talk)

Hellgren Kotaleski J, Lindskog M, Blackwell KT (2005) Effect of temporal pattern on dopamine activated second messenger pathways, Soc Neurosci. Abstr.

Hellgren Kotaleski J, Lindskog M, Blackwell KT (2004) DARPP-32 acts as a temporal integrator - Results from a computer model, (abstract, IBAGS VIII, Scotland)

Hellgren Kotaleski J, Plenz D, Blackwell KT (2004) Background inputs and KA current influence firing of striatal fast spiking interneurons, Soc Neurosci. Abstr. (selected for oral presentation)

Hellgren Kotaleski J, Blackwell KT (2002) Organization of synatic inputs to striatal fast spiking interneurons, Soc Neurosci. Abstr.

Lindskog M, Blackwell KT, Wikstrom M Hellgren Kotaleski J (2002) A kinetic model on DARPP-32 and the PKA/PP1 cascade, Soc Neurosci. Abstr.

Yang K-H, Hellgren Kotaleski J, Blackwell KT (2000) The role of protein kinase C in the temporal specificity of Purkinje cells, Soc Neurosci. Abstr 26:718. (poster and abstract at Neuroscience meeting, New Orleans, 2000)

Hellgren Kotaleski J, Lansner A, Grillner S (1998) Production of phase lag in chains of neural networks oscillating through an escape mechanism. In: Computational Neuroscience: Trends in Research, Plenum Press, ed: J M Bower, p 65-70.

Lansner A, Hellgren Kotaleski J, Ullström M, Grillner S (1998) Local spinal modulation of the calcium dependent potassium channel underlying slow adaptation in a model of the lamprey CPG. In: Computational Neuroscience: Trends in Research, Plenum Press, ed: J M Bower, p 429-434.

Ullström M, Lansner A, Hellgren Kotaleski J, Grillner S (1998) Significance of modulated adaptation for rhythm generation and intersegmental co-ordination in lamprey. In: Computational Neuroscience, Trends in research, Plenum Press, New York, ed: J. Bower, pp:561-565 (Computation and Neural systems 1997, Big Sky, Montana, Oral presentation 20 min by Ullström)

Lansner A, Hellgren Kotaleski J, Ullström M, Grillner S (1997) Modulating the calcium dependent potassium conductance in a model of the lamprey CPG. In: Computational Neuroscience, Trends in research, Plenum Press, New York, ed: J. Bower, pp:365-370

Tegnér J, Hellgren Kotaleski J, Lansner A, Grillner S (1997) A computational and experimental study of rebound firing and modulatory effects on the lamprey spinal network. In: Computational Neuroscience, Trends in research, Plenum Press, New York, ed: J. Bower, pp:519-524

Tegnér J, Hellgren Kotaleski J, Lansner A, Grillner S (1996) Computer simulations of low voltage activated calcium channels in the lamprey spinal network. Nordisk Förenings för Fysiologi vårmöte, KI, Stockholm

Wadden T, Hellgren J, Lansner, Grillner S (1996) Intersegmental coordination in the lamprey: Simulations using a continuous network model. Nordisk Förenings för Fysiologi vårmöte, KI, Stockholm

Wadden T, Hellgren J, Lansner, Grillner S (1995) Simulations of the intersegmental coordination during swimming in the lamprey using a continuous network model. In: Neurobiology of Computation. The Proceedings of the Third Annual Computation and Neural Systems Conference, ed: J M Bower, Kluwer Academic Publisher, pp 353-358.

Hellgren J, Wadden A, Lansner, Grillner S (1994) A continuous network model of the lamprey swimming rhythm generator - intersegmental coordination. Soc Neurosci. Abstr 20:1592.

Hill R, Hellgren J, Grillner S (1994) Whole cell voltage clamp techniques in intact lamprey spinal cord and brainstem (Nordiska Föreningen i Göteborg, maj)

Wikström M, Hellgren J, Hill RH, Grillner S (1994) A 5-HT1A like receptor modulates fictive locomotion and the slow AHP in the lamprey. 3rd inphar satellite meeting on serotonin, Chicago 94

Wikström M, Hellgren J, Hill RH, Grillner S (1994) 5-HT1A like receptors modulates network output pattern for locomotion (Nordiska Fysiologiska Föreningen, Göteborg, maj)

Wikström M, Hellgren J, Hill RH, Grillner S (1993) Classification of the receptor responsible for the 5-HT effect on Ca-dependent K-channels in the lamprey. Suppl no6. Eur J Neurosci, p 108

Hellgren J, Kellerth J-O (1987) Reflex plasticity following lesion of afferent input versus target neurons. Suppl to Neuroscience, vol 22, p. 221